Acute porphyrias are a group of rare genetic metabolic disorders, caused by a defect in one of the enzymes involved in the heme biosynthesis, which results in an abnormally high accumulation of toxic intermediates.Acute porphyrias are characterized by potentially life-threatening attacks and, for some patients, by chronic manifestations that negati
Global warming is having a great impact on the Arctic region, due to the change of air temperature and precipitation.As a consequence, the glacial ice melts and englacial materials are being transported into the ocean.These substances can constitute a source of nutrients in food webs or, on the contrary, a source of contaminants.In this 5.7 prochar
Abstract Background The ability to predict the spatial frequency of relapses in multiple sclerosis (MS) would enable physicians to decide when to intervene more aggressively and to plan clinical trials more accurately.Methods In the current study our objective was to determine if subsets of genes can predict the time to the next acute relapse in pa
Abstract Background Long-acting injectable cabotegravir plus rilpivirine (LAI CAB/RPV) has several potential benefits over daily oral formulations for HIV treatment, including the potential to facilitate long-term adherence and reduce pill fatigue.We aimed to assess facilitators of and barriers to LAI CAB/RPV implementation and delivery through the
Metabolomics aims to systematically profile various small molecules (i.e., metabolites and lipids) in biological samples.Compared with jomeed furniture genomics, transcriptomics and proteomics, metabolomics locates in the downstream of omics technologies, which links genotype with phenotype.Metabolomics is an important part of system biology.It has